Beilstein J. Org. Chem.2024,20, 638–644, doi:10.3762/bjoc.20.56
, demonstrating the effectiveness of our approach in the generation of structural analogues of meroterpenoids.
Keywords: biosynthesis; meroterpenoids; natural products; pathwayengineering; terpene cyclases; Introduction
Meroterpenoids are a class of natural products partially biosynthesized from a terpenoid
-derived counterpart of 3, displayed weaker activity against the two bacterial strains and was not active at the concentration of 500 µg/mL. Thus, the lack of the C-5′ methyl group somehow contributes to the biological activity of 3.
Conclusion
We employed a pathwayengineering approach to create a series
biosynthetic processes, as reported in a recent study that yielded new DMOA-derived meroterpenoids with a monocyclic terpenoid moiety through pathwayengineering [23]. Furthermore, the meroterpenoids produced in this study could be accepted by downstream enzymes in each pathway, further expanding the
PDF
Graphical Abstract
Figure 1:
Biosynthesis of selected fungal meroterpenoids. (A, B) Dearomatizing prenylation reactions in the b...
Beilstein J. Org. Chem.2019,15, 2889–2906, doi:10.3762/bjoc.15.283
functional promiscuity of terpene biosynthetic pathways renders terpene biosynthesis susceptible to rational pathwayengineering using the latest developments in the field of synthetic biology. These engineered pathways will not only facilitate the rational creation of both known and novel terpenoids, their
.
Keywords: bacterial sesquiterpenes and diterpenes; cytochrome P450; pathwayengineering; synthetic biology; terpene biosynthesis; terpene cyclase; Introduction
Evolutionary diversification of terpene biosynthetic pathways has resulted in the largest and most structurally diverse class of specialized
placed on terpene pathways from bacteria, as their biosynthetic pathways usually have the genes encoding the terpene cyclase and modifying enzyme in close proximity, which simplifies both analysis and pathwayengineering. The review will begin with a brief description of terpene families with a special